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Journal of Veterinary Diagnostic Investigation Vol. 21 Issue 6, 821-825
Copyright © 2009 by the American Association of Veterinary Laboratory Diagnosticians
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Full Scientific Reports

Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors

Ricardo De Francisco Strefezzi1, José Guilherme Xavier, Silvia Regina Kleeb and José Luiz Catão-Dias

Correspondence: 1Corresponding Author: Ricardo De Francisco Strefezzi, Rua Coronel Camisão, 363 – ap. 101 – Vila Gomes, São Paulo/SP-CEP: 05590-120 Brazil. rstrefezzi{at}gmail.com

Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology.

Key Words: Cytology • cytopathology • dogs • histopathology • mast cell tumor • mastocytoma • morphometry






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