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Journal of Veterinary Diagnostic Investigation Vol. 20 Issue 3, 346-349
Copyright © 2008 by the American Association of Veterinary Laboratory Diagnosticians
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Brief Communication

Neurological disease in cattle in southern Brazil associated with Bovine herpesvirus infection

Daniel Ricardo Rissi, Felipe Pierezan, Mariana Sá e Silva, Eduardo Furtado Flores and Claudio Severo Lombardo de Barros1

Correspondence: 1Corresponding Author: Claudio Severo Lombardo de Barros, Departamento de Patologia, Laboratório de Patologia Veterinária, Universidade Federal de Santa Maria, Campus Camobi 99105-900, Santa Maria, RS, Brazil, e-mail: claudioslbarros{at}uol.com.br

The occurrence of neurological disease in cattle caused by Bovine herpesvirus in 11 farms from southern Brazil between 1987 and 2007 is described. Twenty-two animals were necropsied. Major clinical signs included excessive salivation, nasal and ocular discharge, circling, recumbency, depression, incoordination, grinding of teeth, and paddling movements. Necropsy findings in 10 of 22 cattle included hyperemia and softening of the rostral portions of the telencephalic cortex, with flattening of gyri, and malacia. Cattle in 10 cases did not show any gross lesions. Histological examination in most cases revealed nonsuppurative and necrotizing meningoencephalitis with acute neuronal necrosis, edema, eosinophilic intranuclear inclusion bodies in astrocytes and neurons, and infiltration of gitter cells. No histologic lesions could be detected in 4 cases. The initial diagnosis was based upon the clinical, epidemiological, and pathological findings. The diagnosis was confirmed by virus isolation in cell culture followed by virus identification by a glycoprotein C–based polymerase chain reaction. Seven isolates were identified as Bovine herpesvirus 5, and 4 were identified as Bovine herpesvirus 1.

Key Words: Bovine herpesvirus • cattle • neurological disease • neuropathology






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