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Journal of Veterinary Diagnostic Investigation Vol. 20 Issue 2, 224-228
Copyright © 2008 by the American Association of Veterinary Laboratory Diagnosticians
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Brief Communications

Association of canine obesity with reduced serum levels of C-reactive protein

Angela P.M. Veiga1, Christopher A. Price, Simone T. de Oliveira, Andréa P. dos Santos, Rómulo Campos, Patricia R. Barbosa and Félix H.D. González

Correspondence: 1Corresponding Author: Angela P.M. Veiga, Université de Montréal–CRRA, Faculté de Médicine Vétérinaire, 3200 Rue Sicotte, Saint-Hyacinthe, Quebec, Canada J2S 7C6, e-mail: angelavet{at}terra.com.br

The prevalence of obesity is increasing in dogs as well as in humans. C-reactive protein (CRP) is an important tool for the detection of inflammation and/or early tissue damage and is linked to obesity in humans. The objective of the present study was to determine if serum CRP levels are altered in obese dogs. Fifteen lean (control group) and 16 overweight (obese group) dogs were examined. Blood samples were collected under fasted conditions for serum determination of CRP, glucose, insulin, cholesterol, triglyceride, and fructosamine. Results indicated that obese dogs were insulin resistant because serum insulin and insulin/glucose ratios were higher than in lean dogs (P ≤ 0.05). Serum CRP concentrations were lower in obese dogs than in controls (P ≤ 0.001). C-reactive protein was negatively correlated with insulin/glucose ratio (R = –0.42) and cholesterol (R = –0.39; P ≤ 0.05). Furthermore, levels of cholesterol, triglycerides, and fructosamine were increased in the obese group compared with the control group. Based on these results, it can be postulated that CRP production is inhibited by obesity and insulin resistance in dogs.

Key Words: Acute phase proteins • dogs • insulin resistance






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