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Journal of Veterinary Diagnostic Investigation Vol. 20 Issue 1, 108-110
Copyright © 2008 by the American Association of Veterinary Laboratory Diagnosticians
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Brief Communications

Lymphangiosarcoma in the nictitating membrane of a horse

Christina Puff1, Vanessa Herder, Andrea Philipp and Wolfgang Baumgärtner

Correspondence: 1Corresponding Author: Christina Puff, Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany. Christina.Puff{at}tiho-hannover.de

A 15-year-old Haflinger gelding presented with a mass in the left nictitating membrane. Two biopsies and the excised nictitating membrane were taken at different time points as a result of reoccurrence of the mass and submitted for histopathologic evaluation. The horse was euthanized as a result of poor prognosis following the reoccurrence of the mass after surgical removal. Histologically, the mass consisted of dilated, thin-walled vascular clefts and channels, lined by flattened to cuboidal endothelial cells with moderate cellular pleomorphism. There was up to 1 mitotic figure per high power field. The channels were empty or contained few erythrocytes. In the collagen-rich stroma, few lymphocytes, focal follicular lymphoid aggregations, and marked lymphangiectasia were observed. Immunohistochemically, the neoplastic cells stained positive for vimentin and partially positive for factor VIII–related antigen. Ultrastructural analysis revealed discontinuous endothelial lining vascular channels that partially lacked a basal membrane. Based on the histopathologic, immunohistochemical, and ultrastructural features lymphangiosarcoma was diagnosed.

Key Words: Horses • lymphangiosarcoma • nictitating membrane • tumor • ultrastructural findings






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