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Journal of Veterinary Diagnostic Investigation Vol. 18 Issue 5, 496-499
Copyright © 2006 by the American Association of Veterinary Laboratory Diagnosticians
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Brief Communication

Renal tubular necrosis and interstitial hemorrhage ("turkey-egg kidney") in a circovirus-infected yorkshire cross pig

Denise M. Imai1, Jennifer Cornish, Robert Nordhausen, John Ellis and N. James MacLachlan

Correspondence: 1Corresponding Author: Denise M Imai, Veterinary Medical Teaching Hospital, University of California, One Garrod Drive, Davis, CA 95616

A juvenile Yorkshire cross pig with rapidly progressive acute renal failure was submitted for necropsy. There was marked edema and disseminated petechiation of both kidneys, producing the "turkey-egg" appearance that is characteristic of exotic diseases such as African and classical swine fever. Microscopic findings included renal tubular epithelial necrosis with extensive interstitial edema and hemorrhage; lymphoplasmacytic, eosinophilic, and histiocytic tubulointerstitial nephritis; and numerous botryoid intracytoplasmic inclusions within the renal tubular epithelium and interstitial macrophages. Porcine circovirus 2 (PCV2) was readily identified within these lesions by both PCV2-specific immunohistochemistical staining and electron microscopy. Tests for African and classical swine fever viruses, as well as bacterial cultures, were negative. The striking renal lesions in this pig were attributed to PCV2 infection and are distinct from those that are typical of other PCV2-associated diseases.

Key Words: Porcine circovirus 2 • renal tubular necrosis • turkey-egg kidney




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Y. Y. Huang, I. Walther, S. A. Martinson, A. Lopez, C. Yason, D. L. Godson, E. G. Clark, and E. Simko
Porcine Circovirus 2 Inclusion Bodies in Pulmonary and Renal Epithelial Cells
Vet. Pathol., September 1, 2008; 45(5): 640 - 644.
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