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Journal of Veterinary Diagnostic Investigation, Vol 18, Issue 3, 291-295
Copyright © 2006 by American Association of Veterinary Laboratory Diagnosticians

Articles

Alpha-fetoprotein in serum and tumor tissues in dogs with hepatocellular carcinoma

S Kitao, T Yamada, T Ishikawa, H Madarame, M Furuichi, S Neo, R Tsuchiya, and K Kobayashi

Dobutsu Medical Center, Osaka, Japan.

Serum alpha-fetoprotein (AFP) concentrations were measured before and after surgical removal of tumor masses in four dogs with hepatocellular carcinoma (HCC). Localization of AFP was also examined immunohistochemically in tumor tissues. In three cases, the serum AFP concentration was 10 to 20 times higher than that of normal dogs. One to two months after surgery, the serum AFP concentration had decreased to normal range. AFP was localized in the tumor tissues in these three cases. One case, which had a low serum AFP, did not show AFP localization in tumor tissue.


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R. E. Tashbaeva, D.-N Hwang, G.-S Song, N.-H Choi, J.-H Lee, Y.-S Lyoo, S.-J Lee, D.-I Jung, H.-Y Kim, and J.-H Sur
Cellular Characterization of Multidrug Resistance P-glycoprotein, Alpha Fetoprotein, and Neovascular Endothelium-Associated Antigens in Canine Hepatocellular Carcinoma and Cirrhotic Liver
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