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Journal of Veterinary Diagnostic Investigation, Vol 18, Issue 3, 287-291
Copyright © 2006 by American Association of Veterinary Laboratory Diagnosticians

Case Reports

Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog

HM Park, AR Doster, RE Tashbaeva, YM Lee, YS Lyoo, SJ Lee, HJ Kim, and JH Sur

Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, KwangJin-Ku 143-701, Korea.

The clinical, hematological, and histopathologic features of megakaryoblastic leukemia (M7) were investigated in a 10-year-old female Shih-Tzu dog. Megakaryoblastic leukemia was diagnosed using anti-human platelet glycoprotein (GP IIIa) and anti-human von Willebrand factor (vWF) antibodies. The expression of CD antigen on megakaryoblasts was also assessed using a CD79a monoclonal antibody. Immunological markers allowed visualization of neoplastic megakaryocytes. Antibodies against platelet GP IIIa were demonstrated to be the most useful for the diagnosis of megakaryoblastic leukemia of paraffin-embedded canine tissues. Hematological and histological data coupled with immunohistochemical reactivity for platelet GP IIIa, vWF, and CD79a antigen in blast cells confirmed a diagnosis of M7 megakaryoblastic leukemia.


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M. WILLMANN, L. MULLAUER, I. SCHWENDENWEIN, B. WOLFESBERGER, M. KLEITER, M. PAGITZ, E. HADZIJUSUFOVIC, S. SHIBLY, M. REIFINGER, J. G. THALHAMMER, et al.
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