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Journal of Veterinary Diagnostic Investigation, Vol 17, Issue 2, 194-197
Copyright © 2005 by American Association of Veterinary Laboratory Diagnosticians

Case Reports

Neuronal ceroid-lipofuscinosis in a Holstein steer

S Hafner, TE Flynn, BG Harmon, and JE Hill

USDA-FSIS, Eastern Laboratory, Russell Research Center, Athens, GA 30604, USA.

A young, partially blind Holstein steer was affected by mild cerebral atrophy. Formalin-fixed cerebral gray matter was diffusely yellow brown. Microscopically, there were eosinophilic, autofluorescent granules primarily in the cytoplasm of cerebral neurons. There was also extensive retinal atrophy with complete loss of the rod and cone layers. Ultrastructural examination of affected cerebral neurons revealed a mixture of granular osmiophilic and lamellar patterns in the cytoplasmic storage bodies. This suggests the existence of neuronal ceroid-lipofuscinosis in the Holstein breed.




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