First outbreak of respiratory disease associated with swine influenza H1N2 virus in pigs in Korea

Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, Kwanak-Gu 151-742, Republic of Korea.

This report describes the first diagnosis of swine influenza H1N2 virus infection in growing pigs in Korea by virus isolation, reverse transcription-polymerase chain reaction (RT-PCR), histopathology, and in situ hybridization. The subtype of swine influenza virus isolates was determined to be H1N2 by RT-PCR. The most consistent and predominant histological feature was bronchointerstitial pneumonia. Lung tissues from these pigs were hybridized with the nonradioactive digoxigenin-labeled complementary DNA (cDNA) probe from H1 HA and N2 NA genes but not from H3 HA and N1 NA genes. A strong hybridization signal was seen in bronchial- and bronchiolar-lining epithelial cells and in alveolar and interstitial macrophages.

This article has been cited by other articles:

				K. Jung and D. S. Song Evidence of the co-circulation of influenza H1N1, H1N2 and H3N2 viruses in the pig population of Korea Vet Rec., July 21, 2007; 161(3): 104 - 105. [Full Text] [PDF]

				J.-Y. Shin, M.-S. Song, E. H. Lee, Y.-M. Lee, S.-Y. Kim, H. K. Kim, J.-K. Choi, C.-J. Kim, R. J. Webby, and Y.-K. Choi Isolation and Characterization of Novel H3N1 Swine Influenza Viruses from Pigs with Respiratory Diseases in Korea J. Clin. Microbiol., November 1, 2006; 44(11): 3923 - 3927. [Abstract] [Full Text] [PDF]