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Journal of Veterinary Diagnostic Investigation, Vol 14, Issue 3, 262-265
Copyright © 2002 by American Association of Veterinary Laboratory Diagnosticians

Case Reports

Solitary dermal leiomyosarcomas in 12 ferrets

I Mikaelian and MM Garner

IDEXX Veterinary Services, West Sacramento, CA 95625, USA.

Twelve 3-6-year-old ferrets (8 males, 3 females, 1 unknown) were presented with single cutaneous nodules. These dermal tumors were characterized histologically by nodular proliferation of neoplastic smooth muscle fibers with marked anisokaryosis and a mitotic rate of >2 mitoses per 10 high-power fields. Neoplastic cells stained strongly for vimentin in all tumors and for smooth muscle actin and desmin in all but 1 tumor. Histologic and immunohistochemical findings suggested a diagnosis of piloleiomyosarcoma for these tumors. Excision was curative in all animals available for follow-up. However, 3 of 5 animals developed adrenal disease within 7 months after removal of the dermal leiomyosarcoma.




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Copyright © 2002 by the American Association of Veterinary Laboratory Diagnosticians, Inc.