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Journal of Veterinary Diagnostic Investigation, Vol 12, Issue 2, 151-153
Copyright © 2000 by American Association of Veterinary Laboratory Diagnosticians

Articles

Porcine postweaning multisystemic wasting syndrome in Korean pig: detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction

C Choi, C Chae, and EG Clark

Department of Veterinary Pathology, College of Veterinary Medicine and School of Agriculture and Biotechnology, Seoul National University, Suwon, Republic of Korea.

This report describes the first diagnosis of porcine circovirus (PCV) infection in weaned pigs with postweaning multisystemic wasting syndrome in Korea by immunohistochemistry and polymerase chain reaction. The most unique lesions were multifocal granulomatous inflammation affecting lymph nodes, liver, and spleen, characterized by infiltrates of epithelioid macrophages and multinucleated giant cells. Circoviral antigen was detected in formalin-fixed sections and was usually present in large, round, dendritic cells in the white pulp of spleen and remnants of follicles in lymph nodes. Lymphoid follicles in the tonsils also contained PCV antigen. A 530-bp DNA fragment of circovirus was successfully amplified from all tested lymph nodes, liver, and spleen.


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